Lab - MTHFR & COMT
Benefits At a Glance
Both MTHFR and COMT genes are involved in the methylation pathway and testing their function is an important component of your anti-aging strategy. Think of billions of on/off switches that control most of your body’s functions such as:
- Brain chemistry is important for mood, anxiety, and stress
- Immune function
- Controlling inflammation
- Energy production
- Detoxification of chemicals and toxins
- Cardiovascular health
When methylation is working, it helps you feel full of energy, in a good mood, and just generally well! When it is not working, you can feel tired, depressed, irritable, run-down, susceptible to infections, foggy-brained, and just plain "toxic." This genetic methylation profile looks for gene variants (also called SNP's) of the following two enzymes:
- MTHFR - (5,10-methylenetetrahydrofolate reductase)
- Research has shown that some people may be at risk of methylation insufficiency due to reduced MTHFR enzyme function.
- Two common variants in the MTHFR gene (C677T and A1298C) may contribute to increased levels of homocysteine, a known risk factor for heart disease, atherosclerosis, and venous thrombosis.
- Those with a genetic variant in MTHFR will have varying levels of difficulty creating the active form of folic acid which is the important form the body needs to function properly.
- Maintaining levels of activated folate may also aid in preventing depression.
- Those with a genetic variant in MTHFR should consider taking activated folate vs. regular folic acid.
- COMT - (Catechol-O-methyltransferase)
- A common variant in COMT, the conversion of the amino acid valine to methionine at position 158 causes a dramatic reduction in its ability to break down neurotransmitters.
- Since COMT is central to dopamine metabolism, variants are associated with lowered stress resiliency, increased sensitivity to pain, and the propensity to worry.
- COMT also plays a role in estrogen metabolism and may lower the cancer-causing potential of metabolites.
*Price includes practitioner interpretation and recommended dietary, lifestyle, and therapeutic interventions.