Ortho Molecular Products


GABAnol is a synergistic combination of gamma-aminobutyric acid (GABA), glycine and established traditional botanicals, which serves as a quick response supplement for muscle relaxation. This unique blend of botanicals, amino acids, vitamins and minerals also work to quickly support muscular discomfort. While other therapies with a similar mechanism may cause dependency when used over time, the natural ingredients in GABAnol are non-habit forming and work quickly to ease muscle tension.

The combination of glycine and GABA act as inhibitory neurotransmitters, which help calm muscles and reduce the activity of the excitatory nervous system that can cause muscle spasms. Together with magnesium, B6 and select botanicals, the ingredients in GABAnol serve as an excellent alternative to valerian-based products. One capsule of GABAnol includes 250 mg GABA, 225 mg glycine, 200 mg cramp bark, and 150 mg Dong Quai.

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GABA, the chief inhibitory neurotransmitter in the central nervous system, plays a key role in regulating muscle excitability. Both GABA and glycine act as calmatives for nerve impulses, controlling muscle contractions. GABA also supports the brain, preventing stress-related messages that trigger muscle spasms from reaching motor centers of the brain by occupying their receptor sites. Cramp bark powder has been used historically for achiness associated with exercise or physical activity, and is one of the most effective natural aids for alleviating exercise-related and female hormone- associated muscle discomfort. Dong quai root extract has also been used for centuries in Chinese traditional medicine, to increase relaxation of the smooth muscles. Magnesium and B6 are known for their immediate effect on muscular relaxation. While other therapies with a similar mechanism may cause dependency when used over time, the natural ingredients in GABAnol are non-habit forming and work quickly to ease muscle tension.

Benefits at a Glance

Promotes Muscle Relaxation

Helps Alleviate Exercise-Related Muscle Pain

Concentrated Blend of Traditional Botanicals to Soothe Muscle Tension

Does Not Contain Gluten, corn, yeast, artificial colors and flavors

Manufacturer's Description

GABA itself is the primary inhibitory neurotransmitter in the brain and regulates other neurotransmissions to prevent overstimulation. One study found that after only 60 minutes of administration, GABA significantly increased alpha brain waves and decreased beta waves compared to water or L-theanine, indicating a significant calming effect on the nervous system. The same study also found GABA to support healthy Ig levels.  A randomized, single-blind, placebo-controlled, crossover- designed study found that among 63 adults given capsules containing 100 mg of GABA or a placebo, those who had taken GABA experienced diminished alpha band and beta band brain waves compared with placebo.

Supplement Facts

Serving Size: 2 capsules

Amount per serving:

Vitamin C (as Ascorbic Acid USP)....40mg

Vitamin B6 (as Pyridoxine HCL USP)....50mg

Magnesium (as DiMagnesium Malate)....15mg

GABA (GAmma Aminobutyric Acid)....250mg

Glycine USP....225mg

Cramp Bark....200mg

Dong Quai Root Extract (Standardized to contain 1% Ligustilide)....150mg


Other ingredients:

Natural Vegetable capsules, Monocrystaline Cellulose, Magnesium Stearate, Stearic Acid and Silicon Dioxide.

Dosage and use

Take 1-2 capsules three times per day or as recommended by your health care professional.

Cautions:   Do not consume this product if you are pregnant or nursing.  Caution is advised for those taking blood thinning medication.

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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.