Homocysteine is a natural amino acid made by the body during the metabolism of the essential amino acid methionine. The pathway between methionine and homocysteine is a cycle - methionine metabolizes to homocysteine, and then recycles back to become methionine. During this cycle, nutrients are synthesized for biochemical reactions such as detoxification, healthy immune function, ideal joint and cartilage structure, and brain and cardiovascular health. The optimal functioning of this pathway depends on enzymes which require many important nutrients, especially B vitamins. Any roadblock during the process can cause an undesirable elevation in homocysteine levels. Stress, poor diet, poor nutrient absorption, and many medications can deplete B vitamins, hindering the process of converting homocysteine back into methionine. The circulation of excess homocysteine in the body can damage the lining of arterial walls, causing them to become narrow and inelastic. The amount of homocysteine in the blood is a great indicator of overall health, with the goal being to maintain a level within a normal range, as determined by your health care practitioner.
Benefits at a Glance
Supports Cardiovascular and Neurologic Health
Supports Healthy Arterial Function
Supports Homocysteine Balance
Maintains Normal Inflammatory Balance
Adequate folate status is critical for maintaining optimal methylation, red blood cell balance, DNA and RNA synthesis and healthy cell division and replication. Folic acid is converted into its metabolically active form, 5-MTHF, by the enzyme methylenetetrahydrofolate reductase (5-MTHFR). 5-MTHF donates its methyl group to vitamin B12 (cobalamin), forming methylcobalamin. Methylcobalamin helps convert the problematic amino acid metabolite homocysteine into the amino acid methionine.
Vitamin B12 (methylcobalamin) works along with folic acid in many body processes, including the synthesis of DNA, red blood cells and supporting health of the myelin sheath, the insulating exterior that surrounds nerve cells. B12 is found primarily in animal foods. Vegetarians and the elderly are at highest risk for B12 deficiency. B12 is considered by many to be a vital nutrient required to balance homocysteine levels. Methylcobalamin is the biologically active form of B12 and supports up-regulation of methylation pathways.
Vitamin B6 (pyridoxine) is a B vitamin that is required for more than 60 different enzymatic reactions that occur in the body. Vitamin B6 works along with folic acid and B12 for in the recycling of homocysteine. B6 also supports a healthy cardiovascular system by promoting healthy platelet aggregation and aids in maintaining healthy blood pressure. Vitamin B6 is required for the activation of lysyl oxidase, an enzyme responsible for the cross-linking of collagen, and elastin, which is crucial for maintaining normal circulation and arterial function.
Trimethylglycine (betaine) functions in the body as a unique methyl donor, supporting liver function and detoxification pathways and the conversion of homocysteine to methionine. Trimethylglycine also works alongside B6, B12 and folic acid in supporting homocysteine balance.
Serving Size: 1 capsule
Amount per serving:
Vitamin B6 (as Pyridoxine HCL USP)..........50mg
Folate........8,500 mcg DFE (5,000 mcg Folic Acid)
Vitamin B12 (as Methylcobalamin)........1000 mcg
Natural Vegetable Capsules, Magnesium Stearate, Stearic Acid, and Calcium Silicate.
Does Not Contain: Wheat, gluten, yeast, soy, corn, animal or dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners or preservatives.
Cautions: If you are pregnant or nursing, consult your physician before taking this product.
Dosage and use
Take 1 or more capsules per day or as recommended by your health care professional.
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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.