Benefits at a Glance
DIM Detox helps regulate healthy estrogen metabolism
May help improve both women and men’s sex hormone balance
May help protect against cancer
The glucosinolates in broccoli, including indole-3-carbinol, and sulforaphane, help support healthy detoxification. BioResponse DIM® provides 25 mg per serving of a highly absorbable form of diindolylmethane, an important metabolite of indole-3-carbinol. These compounds promote healthy estrogen metabolism and cell cycle activity. Calcium-D- glucarate targets beta-glucuronidase enzyme activity, promoting healthy hormone detoxification through the glucuronidation pathway. Lignans, such as 7-hydroxymatairesinol (HMR), are converted in the body to enterolactone. Research indicates that dietary intake of lignans and healthy serum enterolactone levels provide support for cellular, heart, breast, bone and cognitive health. Silymarin, alpha lipoic acid and n-acetyl-l-cysteine act to support phase II detoxification enzyme activity in the liver and offer antioxidant support for cellular protection. Taurine, glycine and methionine promote phase II detoxification pathways and healthy cell metabolism.
DIM Detox promotes healthy cell cycle function and hormone metabolism to support the liver's natural detoxification process and cellular health.
HMRlignan® is a trademark of Linnea Inc.
BioResponse DIM® is a trademark of BioResponse, L.L.C., Boulder. CO. U.S. Patent 6,086,915.
This product contains calcium D-glucarate, the use of which is licensed from Applied Food Sciences, LLC and protected by U.S. Patent 4,845,123.
There are several important uses for DIM (Diindolylmethane) but I want to briefly discuss one major one here.
Most women are concerned about breast cancer and other estrogen driven cancers, and rightfully so. Many studies that get reported in the media talk about the dangers of estrogens, but estrogen has over 400 crucial functions in your body and you need optimal estrogen levels to be healthy.
While estrogen driven cancers are undoubtedly a real concern, simply making estrogen the target is an oversimplification. A real concern with estrogen and cancer involve the following:
- Exposure to xenoestrogens which are endocrine disruptors and alter the normal function of hormones. Stated another way, they look enough like the estrogens that our body gets confused and responds to them. These are found in many skincare and cosmetic products, plastics, processed foods, and insecticides just to name a few.
- Taking synthetic estrogen replacement products, especially oral administration of estrogen.
- The metabolism of estrogen in the body.
Regardless of whether your body makes the estrogen or it gets into your body as xenoestrogens or estrogen replacement therapy, your body must metabolize it and excrete the metabolites (break down products) from the body.
There are several metabolites that can result from the break-break down of these hormones and how you metabolize estrogen is important. The possible metabolites include:
- The 2-hydroxy estrogens which are believed to be the “good estrogens” and are thought to be anti-cancerous.
- The 16- and 4-hydroxy estrogens are believed to be associated with an increased risk of breast cancer.
What is important here is that while genetics can play a role in how your estrogens are metabolized, it is also heavily influenced by diet, nutrition, and moderate exercise, all of which increase your good estrogens. These metabolic pathways are driven by enzymes which come from good nutrition.
If you have never had your estrogen metabolites tested, I would recommend you consider doing so. It is a simple urine test that will measure the way your body is breaking down the estrogen.
If you find you are converting estrogen to the forms that increase the risk of cancers, you can influence this pathway and shift it to the safer 2-hydroxy pathway through improved lifestyle and diet.
DIM (diindolylmethane) which is a concentrated form of the protective ingredient found in cruciferous vegetables influences the conversion of the “good” estrogen in the liver. It is believed this is why DIM has been shown to protect against cancer in many studies.
Nutr Rev. 2016 Jul;74(7):432-43. doi: 10.1093/nutrit/nuw010. Epub 2016 May 31.
Chemopreventive properties of 3,3'-diindolylmethane in breast cancer: evidence from experimental and human studies.
Dalessandri KM, Firestone GL, Fitch MD, et al. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Journal of Nutrition and Cancer. 2004;50(2):161-7.
Wang Z, Yu W, et al. Induction of growth arrest and apoptosis in human breast cancer cells by 3,3- diindolylmethane is associated with induction and nuclear localization of p27kip. Mol Cancer Ther. 2008 Feb;7(2):341-9.
Serving Size: 2 Capsules
Amount per serving
(complex of starch, diindolylmethane, d-alpha tocopheryl succinate, phosphatidylcholine and silica)
(standardized to contain 25% diindolylmethane)
(Brassica oleraceaitalica) sprout concentrate (whole plant)
(standardized to contain a minimum of 400 mcg sulforaphane)
Alpha lipoic acid .....200 mg
N-acetyl-l-cysteine (free form) .....200mg
Milk thisle (silybummarianum) extract (seed) .....150mg
[standardized to contain 80% silymarin]
l-methionine (free form) ..... 200mg
Glycine (free form) ..... 100mg
Taurine (free form) .....100mg
Contains Soy (phosphatidylcholine)
Other ingredients: hypoallergenic plant fiber (cellulose), ascorbyl palmitate, silica, vegetarian capsule (cellulose, water)
Dosage and use
- 2 capsules daily, with meals.
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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.