Muscle Protect (with HMB)

Douglas Labs

Muscle Protect (with HMB)

Muscle Protect ™ with HMB ® supports increased protein synthesis and lean muscle preservation in a convenient powdered beverage.
Regular price $64.00

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β-Hydroxy-β-methylbutyrate (HMB) is a metabolite of leucine that supports lean muscle mass through two unique mechanisms: decreased muscle degradation and increased protein synthesis. Vitamin D and glutamine provide additional support for muscle health.


Maintaining skeletal muscle mass and function is important for sustaining health throughout the lifespan.  Physically inactive people can lose as much as 3% to 5% of their muscle mass for every 10 years past the age of 40.  Even physically active people can experience at least some level of muscle loss.  Among the blood amino acids, the essential amino acids (EAAs) are primarily responsible for the regulation of muscle protein synthesis, and among them, leucine has an important role in the regulation of muscle protein synthesis. Calcium β-Hydroxy-β-methylbutyrate-monohydrate (HMB) is a metabolite of leucine that decreases protein breakdown after a resistance workout by disrupting the ubiquitin-proteasome proteolytic pathway. Several studies have indicated that HMB also stimulates protein synthesis through the activation of the mTOR pathway.

Research involving physically active older adults has shown improvement in subjects’ muscle strength and function when HMB was included in their health routines. Although leucine offers similar benefits to HMB in increasing protein synthesis, HMB is more potent than leucine for promoting strength gains due to the dual benefit HMB provides in decreasing protein breakdown. Additionally, with 5% of leucine converted to HMB, it would take consuming 60 grams of leucine to produce 3 grams of HMB.

The Amino 9TM blend of essential and branched-chain amino acids has been clinically shown to boost muscle protein balance by increasing anabolism and limiting catabolism. Supplemental essential amino acids support muscle protein balance more than BCAAs alone. In a human clinical trial with elderly and young subjects where BCAAs were shown to stimulate 22% more muscle protein synthesis (MPS) than placebo, complementing them with all EAAs had 50% better MPS than BCAAs alone.

Vitamin D3 has a positive effect on muscle protein and energy metabolism and is, therefore, necessary for healthy muscle function. Glutamine is an amino acid that acts as an essential substrate for enterocytes and immune cells, and its deficiency decreases protein synthesis in skeletal muscle. Therefore, adequate levels of both vitamin D and glutamine in the body may support healthy muscles.

Benefits at a Glance

Supports healthy muscle mass and muscle function

Provides anabolic muscle-building support

Attenuates muscle protein breakdown and preserves lean muscle mass in both young and older adults

Manufacturer's Description

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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.