SPM Active

SPM Active is designed to help support the body’s natural capacity to respond to physical challenges and resolve the immune response.


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    SPM Active is a revolutionary nutritional product developed through advanced fractionation technology featuring standardized levels of SPMs (specialized pro-resolving mediators) found in fish oil. SPMs play a key role in the resolution (i.e., completion) of an immune response, according to extensive preclinical research.


    Acute inflammation is a protective immune response that occurs in an attempt to eliminate invading pathogens and repair injured tissue. Poor food choices have also been linked to inflammation. If left unresolved a prolonged state of chronic inflammation that causes damage can occur and result in pain and/or chronic disease. Many chronic diseases such as cardiovascular disease, arthritis, osteoporosis, diabetes, metabolic syndrome, inflammatory bowel disease, periodontal disease, asthma, and age-related macular degeneration, as well as some neurological disorders such as dementia and Alzheimer’s, have been linked to chronic inflammation.

    The acute inflammatory response (initiation phase) begins within seconds to minutes following the presence of harmful stimuli such as pathogens, injuries, or irritants (which can include environmental toxins and processed food). The most well-known responders are white blood cells that travel from the bloodstream into the inflamed site and surround the area.

    Then comes the resolution phase. Previously thought to be a passive process, new research shows resolution is an active process controlled by specialized pro-resolving mediators (SPMs) that are produced in tissue exudates during the resolution phase and function to accelerate the return to normal.

    To return to normal, the white blood cells present in the area of damage need to be removed from the inflamed site and white blood cells on their way to the site need to be stopped. If they are allowed to continue to the site, they would cause additional tissue damage and continued inflammation. This is true whether the damage is a cut on the finger or damage in the blood vessels.

    In the resolution phase of acute inflammation, long-chain polyunsaturated fatty acids (PUFAs) in tissue are converted into SPMs. The majority of SPMs are biosynthesized from omega-3 fatty acids such as EPA and DHA. These SPMs have shown to be pro-resolving when administered to animal models with human disease.

    Although EPA and DHA (ingredients of typical fish oil capsules) can be converted to SPMs, they do not have the properties of SPMs. For decades, drugs such as COX-2 inhibitors or non-steroidal anti-inflammatory drugs (NSAIDs) have been the therapy of choice for many acute and chronic inflammatory conditions. Keep in mind that anti-inflammation is not the same as resolution.

    Since initiation phase activities are required to ever get to the resolution phase, traditional COX-2 and lipoxygenase inhibitors may delay resolution activities and prevent the body’s attempt to return to normal and allow tissue healing.

    Thus, SPMs are an important key to controlling and resolving inflammation and subsequently preventing chronic inflammatory conditions. The fact that SPMs are enzymatically produced from long-chain PUFA (especially EPA and DHA) in tissue exudates indicates the indispensable role of nutrition in regulating inflammation and promoting resolution.

    This product is designed to provide the SPM’s necessary to resolve the inflammatory process. Remember you must also identify the cause of inflammation and remove that trigger to avoid the return of inflammation. While I highly recommend this product, I don’t recommend taking it long term. It should only be needed until the inflammatory process is resolved.

    Benefits at a Glance

    Controls and resolves inflammation

    Supports healthy immune cell resolution-related activities

    SPMs are an important key to controlling and resolving inflammation and subsequently preventing chronic inflammatory conditions.

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    DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.