OmegaGenics SPM Active (60 ct) by Metagenics


OmegaGenics SPM Active

A breakthrough in tissue health and immune response support

Controls and resolves inflammation

Supports healthy immune cell resolution-related activities

SPMs are an important key to controlling and resolving inflammation and subsequently preventing chronic inflammatory conditions.

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OmegaGenics SPM Active is a revolutionary nutritional product developed through advanced fractionation technology featuring standardized levels of SPMs (specialized pro-resolving mediators) found in fish oil. SPMs play a key role in the resolution (i.e., completion) of an immune response, according to extensive preclinical research.


  • A breakthrough in tissue health and immune response support
  • Supports healthy immune cell (i.e., macrophage) resolution-related activities
Patent pending.



Acute inflammation is a protective immune response that occurs in an attempt to eliminate invading pathogens and repair injured tissue. Poor foods choices have also been linked to inflammation. If left unresolved a prolonged state of chronic inflammation that causes damage can occur and result in pain and/or chronic disease. Many chronic diseases such as cardiovascular disease, arthritis, osteoporosis, diabetes, metabolic syndrome, inflammatory bowel disease, periodontal disease, asthma, and age-related macular degeneration, as well as some neurological disorders such as dementia and Alzheimer’s, have been linked to chronic inflammation.

The acute inflammatory response (initiation phase) begins within seconds to minutes following the presence of harmful stimuli such as pathogens, injuries, or irritants (which can include environmental toxins and processed food). The most well-known responders are white blood cells that travel from the blood stream into the inflamed site and surround the area.

Then comes the resolution phase. Previously thought to be a passive process, new research shows resolution is an active process controlled by specialized pro-resolving mediators (SPMs) that are produced in tissue exudates during the resolution phase and function to accelerate the return to normal.

To return to normal, the white blood cells present in the area of damage need to be removed from the inflamed site and white blood cells on their way to the site need to be stopped. If they are allowed to continue to the site, they would cause additional tissue damage and continued inflammation. This is true whether the damage is a cut on the finger or damage in the blood vessels.

In the resolution phase of acute inflammation, long-chain polyunsaturated fatty acids (PUFAs) in tissue are converted into SPMs. The majority of SPMs are biosynthesized from omega-3 fatty acids such as EPA and DHA. These SPMs have shown to be pro-resolving when administered to animal models with human disease.

Although EPA and DHA (ingredients of typical fish oil capsules) can be converted to SPMs, they do not have the properties of SPMs. For decades, drugs such as COX-2 inhibitors or non-steroidal anti-inflammatory drugs (NSAIDs) have been the therapy of choice for many acute and chronic inflammatory conditions. Keep in mind that anti-inflammation is not the same as resolution.

Since initiation phase activities are required to ever get to the resolution phase, traditional COX-2 and lipoxygenase inhibitors may delay resolution activities and prevent the body’s attempt to return to normal and allow tissue healing.

Thus, SPMs are an important key to controlling and resolving inflammation and subsequently preventing chronic inflammatory conditions. The fact that SPMs are enzymatically produced from long-chain PUFA (especially EPA and DHA) in tissue exudates indicates the indispensable role of nutrition in regulating inflammation and promoting resolution.

This product is designed to provide the SPM’s necessary to resolve the inflammatory process. Remember you must also identify the cause of inflammation and remove that trigger to avoid the return of inflammation. While I highly recommend this product, I don’t recommend taking it long term. It should only be needed until the inflammatory process is resolved.


Majno G, Joris I. Cells, Tissues, and Disease: Principles of General Pathology: Oxford University Press, USA; 2004. Spite M, Claria J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014;19:21-36.

Serhan CN. Pro-resolving lipid mediators are leads for resolution physiology. Nature. 2014;510:92-101.

Serhan CN, Brain SD, Buckley CD, et al. Resolution of inflammation: state of the art, definitions and terms. Faseb J. 2007;21:325-332.

Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007;447:869-874.

Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN. Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol. 2001;2:612-619.

Serhan CN, Clish CB, Brannon J, et al. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med. 2000;192:1197-1204.

Serhan CN, Petasis NA. Resolvins and protectins in inflammation resolution. Chem Rev. 2011;111:5922-5943.

Serhan CN. Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol. 2010;177:1576-1591.

Navarro-Xavier RA, Newson J, Silveira VL, et al. A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties. J Immunol. 2010;184:1516-1525.

Chan MM, Moore AR. Resolution of inflammation in murine autoimmune arthritis is disrupted by cyclooxygenase-2 inhibition and restored by prostaglandin E2-mediated lipoxin A4 production. J Immunol. 2010;184:6418-6426.

Serving Size: 2 Softgels

Amount per serving

Calories 5

Calories from Fat 5

Total Fat 0.5g

Cholesterol <5mg

Active Portion of Fractionated Marine Lipid Concentrate ..... 250mg

SPM content standardized to

18-hydroxy-eicosapentaenoic acid (18-HEPE) and

17-hydroxy-docosahexaenoic acid (17-HDHA)

Other ingredients: Fractionated marine lipid concentrate [(anchovy and sardine oil, and mixed tocopherols (antioxidant)], softgel shell (gelatin, glycerin, water, pectin, and sorbitol), and lemon oil. Contains: Fish (anchovy and sardine).

Dosage and use

    • Take two softgels once daily or as directed by your healthcare practitioner.

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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.