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Osteoarthritis is the most common form of arthritis or inflammation of the joints. Osteoarthritis (or OA) is painful and degenerative and can damage sensitive cartilage, decreasing the protection and cushioning of bones and joints. Over time inflammation associated with OA damages cartilage and leads to pain, deformity, and loss of movement and mobility.
Osteoarthritis (OA) affects approximately 50 million US adults or 1 in 5 individuals, and most individuals over the age of 65 have signs and symptoms of OA [Centers for Disease Control (CDC), 2011].
Factors that can lead to increased oxidative stress and damage to joints and connective tissue include:
Aging - aging typically results in a decrease in cartilage volume, proteoglycan content, and cartilage vascularization and perfusion.
Sex – women are more likely to have OA in the hands, feet a knee; OA in the hip are prevalent equally in both sexes.
Obesity - being overweight or obese increases stress to weight-bearing joints, including knees and hips.
Joint injury/stress - a traumatic injury to joints can result in damage to cartilage, ligaments or menisci and possibly lead to premature deterioration.
Food choices – high glycemic foods (refined carbohydrates/sugars), low omega-3 fatty acids can lead to increased oxidative stress and symptoms of joint/muscle aches/pains.
Increased physical exertion
Drug use including opiates, corticosteroids, and NSAIDs. Opiates can imbalance Th1 and Th2 immunity, leading to inflammatory responses and imbalanced immunity. NSAIDs and corticosteroids can deplete essential nutrients necessary in a healthy musculoskeletal system.
Lack of quality sleep
Gastrointestinal imbalances in the microflora
Non-steroidal anti-inflammatory drugs (NSAIDS), such as aspirin, ibuprofen (Advil, Motrin), and naproxen (Alleve), are drugs commonly used to relieve symptoms associated with musculoskeletal pain and inflammation, including when associated with intense exercise and physical training. NSAIDs can impair kidney function and lead to electrolyte imbalances, especially in those training and athletes. It is also reported that NSAIDs can cause a breakdown of glycosaminoglycan synthesis, which can speed up the articular damage in arthritic conditions.
Benefits at a Glance
Supports connective tissue
Amount per serving:
Dosage and use
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DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.