SAMe is a principle methyl donor for biochemical reactions throughout the body. This methyl transfer is critical to reactions involving proteins, phospholipids, DNA, RNA, creatine, hormones, development of cell membranes, degradation of histamine, and formation of norepinephrine and dopamine. Once methyl groups have been removed or donated, SAMe is converted into homocysteine. Homocysteine can either be recycled back into methionine (a process known as transmethylation, which is dependent on vitamin B12 and folate) or metabolized via trans-sulfuration (a vitamin B6 and betaine dependent pathway), to eventually contribute to reduced glutathione and taurine production. These pathways rely heavily on sufficient stores of these B vitamins.3
Benefits at a Glance
Provides Mood Support
Supports Musculoskeletal Health
Supports Liver Health
S-Adenosylmethionine (SAMe) is the active methyl form of the amino acid methionine. SAMe is necessary for an array of biochemical pathways, including neurotransmitter synthesis, metabolism of homocysteine, and detoxification. As a donator of methyl groups, SAMe supports glutathione production, liver health, musculoskeletal and joint comfort, and a positive mood. Pathways utilizing SAMe are dependent on B vitamin cofactors, therefore, this formulation of SAMe includes vitamin B6 (4 mg), 5-methyltetrahydrofolic acid (400 mcg), and vitamin B12 (100 mcg).
Serving Size: 2 capsules
Amount per serving:
Folate (as Quatrefolic® (6S)-5-Methyltetrahydrofolic acid glucosamine salt)..........400mcg
SAMe (as S-Adenosyl-L-methionine disulfate p-toluensulfonate)..........400mg
Natural vegetable capsules, Microcrystalline Cellulose, Silicon Dioxide, and Magnesium Stearate.
Does Not Contain: Gluten, corn, yeast, artificial colors and flavors.
Dosage and use
Take 1 or 2 capsules two times per day or as recommended by your healthcare professional.
Cautions: Do not consume this product if you are pregnant or nursing.
Read our story
on healthy healing!
DISCLAIMER: Statements made are for educational purposes and have not been evaluated by the US Food and Drug Administration. They are not intended to diagnose, treat, cure, or prevent any disease. If you have a medical condition or disease, please talk to your doctor prior to using the recommendations given.